DIVING THROUGH MEMBRANES: MOLECULAR CUNNING TO ENFORCE THE ENDOSOMAL ESCAPE OF ANTIBODY-TARGETED ANTI-TUMOR TOXINS

Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted Anti-Tumor Toxins

Membranes are vital barriers by which cells control the flux of molecules and energy between their exterior and interior and also between their various intracellular compartments.While numerous transport systems exist for ions and small molecules, the cytosolic uptake of larger biological molecules and gtech brush bar in particular antibody-targete

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An antimicrobial peptide specifically active against Listeria monocytogenes is secreted by Bacillus pumilus SF214

Abstract Background Members of the Bacillus genus produce a large variety of antimicrobial peptides including linear or cyclic lipopeptides and thiopeptides, that often have a broad click here spectrum of action against Gram-positive and Gram-negative bacteria.We have recently reported that SF214, a marine isolated strain of Bacillus pumilus, produ

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Analysis of the Similarity of Flavoring Characteristic of Plant-based Meat Alternatives with Meat Products Based onGC-O-MS Technology

In order to investigate the flavor properties of commercial plant-based meat alternatives (PMAs) and the similarity of PMAs with meat products, this experiment used solid-phase microextraction (SPME) in conjunction with gas chromatography-olfactometry-mass spectrometry (GC-O-MS) to identify and analyze the volatile flavor compounds in three types o

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Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression.

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, with grim prognosis in a half of patients.Exosomes are nanometer-sized membrane vesicles derived from the multivesicular bodies (MVBs) of the endocytic pathway and released by normal and neoplastic cells.Tumor-derived exosomes have been shown in different model systems to

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